Expression of Phosphodiesterase 4 Memory T Cells by HIV - 1 + Infection of CD 4

T Lymphocytes in AIDS Patients With Tuberculosis

CD 4 + and CD 8 + T lymphocyte counts, naive and memory/effector CD 4 + T subpopulations, and the expression of CD 38 on CD 8 + T lymphocytes were evaluated in four groups: AIDS patients with tuberculosis (HIV/TB, n=14), HIV-1 infected patients (HIV, n=10), HIV-1 negative patients with tuberculosis (TB, n=20) and healthy controls (CTL, n=17). TB and HIV had fewer CD 4 + T cells than CTL, with t...

Expression of Integrin Type 1 Infection Regardless of Their Preferential Targets for Productive HIV T Cells Are + CD 4 + Memory CCR

HIV - Type 1 Productive Infection with X 4 and R 5 T Cells More Susceptible to + Memory CD 4 TLR 2 Signaling Renders Quiescent

Turnover of CD 4 1 and CD 8 1 T Lymphocytes in HIV - 1 Infection as Measured by Ki - 67 Antigen

We investigated CD4 1 and CD8 1 T cell turnover in both healthy and HIV-1–infected adults by measuring the nuclear antigen Ki-67 specific for cell proliferation. The mean growth fraction, corresponding to the expression of Ki-67, was 1.1% for CD4 1 T cells and 1.0% in CD8 1 T cells in healthy adults, and 6.5 and 4.3% in HIV-1–infected individuals, respectively. Analysis of CD45RA 1 and CD45RO 1...

Expression of Recombinant Phosphodiesterase 3A and 3B Using Baculovirus Expression System

Background: Phosphodiesterase 3A (PDE3A) and phosphodiesterase 3B (PDE3B) play a critical role in the regulation of intracellular level of adenosine 3´,5´-cyclic monophosphate (cyclic AMP, cAMP) and guanosine 3´,5´-cyclic monophosphate (cyclic GMP, cGMP). Subsequently PDE3 inhibitors have shown to relax vascular and inhibit platelet aggregation in cardiovascular disease. Objectives: In th...